Dr. Ghosh is a scientist in biomedical research that encompasses immunology, cancer biology, genetics and aging associated disorders. Amiya obtained his PhD on life Sciences from Jadavpur University, India and migrated to USA to pursue his research career. Beginning as a research fellow at Harvard Medical School, studied the functional role of Cbl in attenuating receptor and non-receptor tyrosine kinase signaling with clinical relevance to immune function and cancer biology. As a team scientist, he had been instrumental in guiding PhD students and post-docs in the laboratory harvesting publications in reputed journals including EMBO, PNAS and JBC as lead author or as co-author. As a post-doctoral fellow at the UConn Health Center, Dr. Ghosh expanded his research to animal models and investigated therapeutic function of capsaicin in cancer models and provided evidence that, apoptotic induction of tumor stroma with phytochemicals was an effective measure of cancer therapy.
In 2008, Dr. Ghosh relocated to University of Michigan and engaged in studies of human genetic diseases involving mutations leading to ciliopathies. He characterized the functional consequences of disease associated mutations of centrosome-cilia associated genes (e.g.; RPGR, RP2, CEP290, SDCCAG) using cell culture, zebrafish and mouse model systems. One of his pioneering discoveries was that ciliopathy genes SDCCAG8 and CEP164, regulated DNA-damage response (DDR) signaling and mutations in these genes that disrupt DDR also promoted premature aging. Dr. Ghosh’s research findings are translated into publications in high impact journals including Human Molecular Genetics, Cell, Nature Genetics and PLOS Genetics. From this point of his career, Dr. Ghosh was interested in the aging biology and decided to join the Division of Geriatric & Palliative medicine as a research Investigator to pursue my scientific endeavor in aging research and contributed in delineating the mechanisms of adipose tissue inflammation in aging. Amiya was awarded with a grant from UM Aging Rodents Core (ARC) in 2013 and a Pilot Grant (peer reviewed by the internal and external experts) from the Pepper Center in 2015 on the proposal that delineate the role of adipose tissue specific autophagy activity in modulating inflammation in aging.
In 2016, Dr. Ghosh was promoted to Research Assistant Professor and has been selected as a University of Michigan Older Americans Independence Center (OAIC) Research Career Development Core (RCDC) KL2 Scholar through a peer review process. As a leading and co-corresponding author, Dr. Ghosh has published five articles in reputed journals of Aging and Journal of Gerontology. Currently, Dr. Ghosh is interested in understanding brain inflammation and its impact on promoting neurodegenerative diseases.